Adelle McFarland
MCB Graduate Student
Education
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Ph.D. University of Washington, Seattle
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B.A. Indiana University Bloomington
Research Interests
Host cells have a sophisticated arsenal of cytoplasmic sensors that monitor for microbes that gain access to the cytosol. Cyclic dinucleotides have emerged as important molecules that are sensed during infection in the cytosol. My work in the Woodward lab focuses on the characterization of a new bacterial cdN specific cytoplasmic sensor and how its interaction with cdNs shapes the immune response.
Email: admcfar@uw.edu
Phone: 206-616-0675
Publications
Abigail Jarret, Adelle P. McFarland, Stacy M. Horner, MeeAe Hong, Samantha Badil, Rochelle C. Joslyn, Darren Baker, Mary Carrington, Curt H. Hagedorn, Michael Gale Jr., Ram Savan. Hepatitis C virus-induced microRNAs dampen type I interferon signaling. Nature Medicine, accepted.
Adelle P. McFarland, Joshua J. Woodward Flying Under the Radar: Immune Evasion by Group B Streptococcus. Cell Host and Microbe. 2016, 20 (1): 4-6.
Adelle P. McFarland, Stacy M. Horner, Abigail Jarret, Rochelle C. Joslyn, Eckart Bindewald, Bruce A. Shapiro, Don A. Delker, Curt Hagedorn, Mary Carrington, Michael Gale Jr., Ram Savan. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. Nature Immunology, 2014 Jan; 15(1):72-79
Folkert Steinhagen*, Adelle P. McFarland*(co-first authors), Luis G. Rodriguez, Poonam Tewary, Abigail Jarret, Ram Savan, Dennis M. Klinman. IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells. European Journal of Immunology, 2013 May; 43(7):1896-1906.
Adelle P. McFarland, Ram Savan, Sagie Wagage, Augustina Addison, Karthika Ramakrishnan, Megan Karwan, Tri Duong, Howard A. Young. Localized Delivery of IFN-β by Lactobacillus Exacerbates Experimental Colitis. PLoS ONE. 2011 Feb; 6(2):e16967.
Ram Savan, Adelle P. McFarland, Della A. Reynolds, Lionel Feigenbaum, Karthika Ramakrishnan, Megan Karwan, Hidekazu Shirota, Dennis M. Klinman, Kieron Dunleavy, Stefania Pittaluga, Stephen K. Anderson, Raymond P. Donnelly, Wyndham H. Wilson and Howard A. Young. A novel role of IL-22R1 as a driver of inflammation. Blood, 2011 Jan; 117(2):575-84.