Innate immune detection
Cyclic dinucleotides have emerged as potent modulators of host inflammation and immunity. During cytosolic infiltration by bacterial pathogens, binding of bacterial cyclic dinucleotides to the host receptor STING results in the activation of a host interferon response. During viral infection or as a consequence of bacterial lysis, the host DNA receptor cGAS triggers production of 2',3'-cGAMP, which also binds and activates STING and interferon production. Activation of these pathways has been implicated in host resistance to infection as well as autoinflammatory disorders. We aim to further detail the role of cyclic dinucleotide detection during infection, using L. monocytogenes as a model.
Model of host immune sensing of cyclic dinucleotides during bacterial and viral infection.
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