B.S. University of California, Los Angeles
Shivam is an MD/PhD student (E-15) at the University of Washington. He completed his B.S. in Biochemistry at the University of California, Los Angeles in 2014. His research interests include signal transduction in host innate immunity with an eye toward understanding the role of cyclic-dinucleotides in modulating host immune responses during both bacterial and viral infections.
Pollock AJ*, Zaver SA*, Woodward JJ A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells. Nat Commun. 2020; 11: 3533.
Zaver SA, Woodward JJ. Cyclic dinucleotides as the forefront of innate immunity. Curr Opin Cell Biol. 2020 Jan 17;63:49-56.
Luteijn RD*, Zaver SA*, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019 Sep;573(7774):434-438.
Reichardt AD, Pindado J, Zaver SA, Cheng G. TRAF protein function in noncanonical NF-κB signaling. Methods Mol Biol. 2015;1280:247-68.
Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 2012 Dec;13(12):1155-61.