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Adelle and Josh Preview Paper by Andrade et al.

Type I IFN production is an important host defense mechanism against Gram-positive Streptococci. In this issue of Cell Host & Microbe, Andrade et al. (2016) report that Group B Streptococcus limits type I IFN by expressing a surface phosphodiesterase that degrades extracellular bacterial cyclic dinucleotides, thereby promoting virulence.

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