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Tu Anh Huynh

Postdoctoral Fellow


  • Ph.D. University of California, Davis

  • B.S. University of New South Wales

Research Interests

My research interest is to investigate bacterial signal transduction that mediates normal physiology and virulence, with a current focus on c-di-AMP signaling. My current projects explore how c-di-AMP accumulation is toxic in bacteria, and how this nucleotide regulates various cellular processes, such as  membrane stability and osmotic stress response.


Phone: 206-616-0675



Huynh, T. N., Choi, P.H., Sureka K., Ledvina H.E., Campillo J., Tong L., and Woodward J.J. (2016). Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol Microbiol. Epub ahead of print

Huynh, T. N., and Woodward, J.J. (2016). Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol. 30, 22-9.
Tu-Anh N. Huynh 1 of 3

Huynh, T. N., Luo, S., Pensinger, D., Sauer J.D., Tong, L., and Woodward, J.J. (2015). An HD-domain protein representing a novel class of c-di-AMP phosphodiesterase in Listeria monocytogenes. Proc Natl Acad Sci USA. 112, E747-56.

Huynh, T. N., Lin, H.Y., Noriega, C.E., Lin, A.V., and Stewart, V. (2015). Crosstalk inhibition nullified by a receiver domain missense substitution. J. Bact. 197:3294-306.


Huynh, T. N., Chen, L.L., amd Stewart, V.J. (2015). Sensor-response regulator interactions in a cross-regulated signal transduction network. Microbiology. 161: 1504-15.

Sureka K., Choi P.H., Precit M., Delince M., Pensinger D.A., Huynh T.N., Jurado A.R., Goo Y.A., Sadilek M., Iavarone A.T., Sauer J.D., Tong L., Woodward J.J. (2014). The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell. 158:1389-401.

Huynh, T. N., Noriega, C.E., and Stewart, V.J. (2013). Missense substitutions reflecting regulatory control of transmitter phosphatase activity in two-component signaling. Mol Microbiol. 88, 459-472.

Seitzer, P., Huynh, T.A., and Facciotti, M.T. (2013). JContextExplorer: a tree-based approach to facilitate cross-species genomic context comparison. BMC Bioinformatics. 14(1). 18. doi:10.1186/1471-2105-14-18.

Huynh, T. N. and Stewart, V.J. (2011). Negative control in two-component signal transduction by transmitter phosphatase activity. Mol Microbiol. 82, 275-86.

Huynh, T. N., Noriega, C.E., and Stewart, V.J. (2010). Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX. Proc Natl Acad Sci USA. 107, 21140-5.

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