The Woodward Laboratory

Education

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• Ph.D. University of California, Davis

• B.S. University of New South Wales
   

Research Interests

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My research interest is to investigate bacterial signal transduction that mediates normal physiology and virulence, with a current focus on c-di-AMP signaling. My current projects explore how c-di-AMP accumulation is toxic in bacteria, and how this nucleotide regulates various cellular processes, such as  membrane stability and osmotic stress response.

Publications

 

Huynh, T. N., Choi, P.H., Sureka K., Ledvina H.E., Campillo J., Tong L., and Woodward J.J. (2016). Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol Microbiol. Epub ahead of print
 

Huynh, T. N., and Woodward, J.J. (2016). Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol. 30, 22-9.
Tu-Anh N. Huynh 1 of 3

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Huynh, T. N., Luo, S., Pensinger, D., Sauer J.D., Tong, L., and Woodward, J.J. (2015). An HD-domain protein representing a novel class of c-di-AMP phosphodiesterase in Listeria monocytogenes. Proc Natl Acad Sci USA. 112, E747-56.
 

Huynh, T. N., Lin, H.Y., Noriega, C.E., Lin, A.V., and Stewart, V. (2015). Crosstalk inhibition nullified by a receiver domain missense substitution. J. Bact. 197:3294-306.

 

Huynh, T. N., Chen, L.L., amd Stewart, V.J. (2015). Sensor-response regulator interactions in a cross-regulated signal transduction network. Microbiology. 161: 1504-15.
 

Sureka K., Choi P.H., Precit M., Delince M., Pensinger D.A., Huynh T.N., Jurado A.R., Goo Y.A., Sadilek M., Iavarone A.T., Sauer J.D., Tong L., Woodward J.J. (2014). The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell. 158:1389-401.
 

Huynh, T. N., Noriega, C.E., and Stewart, V.J. (2013). Missense substitutions reflecting regulatory control of transmitter phosphatase activity in two-component signaling. Mol Microbiol. 88, 459-472.
 

Seitzer, P., Huynh, T.A., and Facciotti, M.T. (2013). JContextExplorer: a tree-based approach to facilitate cross-species genomic context comparison. BMC Bioinformatics. 14(1). 18. doi:10.1186/1471-2105-14-18.

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Huynh, T. N. and Stewart, V.J. (2011). Negative control in two-component signal transduction by transmitter phosphatase activity. Mol Microbiol. 82, 275-86.

Huynh, T. N., Noriega, C.E., and Stewart, V.J. (2010). Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX. Proc Natl Acad Sci USA. 107, 21140-5.

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